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1

“Phase I and Phase II” Drug Metabolism: Terminology that we Should Phase Out?

David Josephy, P., Peter Guengerich, F., Miners, John O.

Journal:

Drug Metabolism Reviews

Year:

2005

Language:

english

File:

PDF, 63 KB

english, 2005

2

The Molecular Toxicology of Acetaminophen

David Josephy, P.

Journal:

Drug Metabolism Reviews

Year:

2005

Language:

english

File:

PDF, 171 KB

english, 2005

3

Metabolic Activation of Aromatic Amine Mutagens by Simultaneous Expression of Human Cytochrome P450 1A2, NADPH-Cytochrome P450 Reductase, and N -Acetyltransferase in Escherichia coli

Josephy, P. David, Evans, David H., Parikh, Asit, Guengerich, F. Peter

Journal:

Chemical Research in Toxicology

Year:

1998

Language:

english

File:

PDF, 97 KB

english, 1998

4

Activation of MeIQ (2-amino-3,4-dimethylimidazo- [4,5-f]quinoline) by sequence variants of recombinant human cytochrome P450 1A2

P. David Josephy, Kathryn L. Bibeau, David H. Evans

Journal:

Environmental and Molecular Mutagenesis

Year:

2000

Language:

english

File:

PDF, 118 KB

english, 2000

5

New developments in the ames assay: High-sensitivity detection of mutagenic arylamines

P. David Josephy

Journal:

Year:

1989

Language:

english

File:

PDF, 663 KB

english, 1989

6

Editorial

P. David Josephy, Pamela M. Klein

Journal:

Environmental and Molecular Mutagenesis

Year:

2002

Language:

english

File:

PDF, 30 KB

english, 2002

7

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells

Heather M. McDiarmid, George R. Douglas, Brenda L. Coomber, P. David Josephy

Journal:

Environmental and Molecular Mutagenesis

Year:

2002

Language:

english

File:

PDF, 184 KB

english, 2002

8

Evidence for the presence of mutagenic arylamines in human breast milk and DNA adducts in exfoliated breast ductal epithelial cells

Patricia A. Thompson, David M. DeMarini, Fred F. Kadlubar, Gail Y. McClure, Lance R. Brooks, Bridgett L. Green, Manal Y. Fares, Angie Stone, P. David Josephy, Christine B. Ambrosone

Journal:

Environmental and Molecular Mutagenesis

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

9

Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains

P. David Josephy, Sarah M. Batty, Darrell R. Boverhof

Journal:

Environmental and Molecular Mutagenesis

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

10

Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen

P. David Josephy, Patricia L. Taylor, Gaby Vervaet, Bengt Mannervik

Journal:

Environmental and Molecular Mutagenesis

Year:

2006

Language:

english

File:

PDF, 478 KB

english, 2006

11

Microenvironmental influences on mutagenesis in mammary epithelial cells

Erzsébet Papp-Szabó, P. David Josephy, Brenda L. Coomber

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 151 KB

english, 2005

12

An electron spin resonance investigation of the iron-catalyzed reaction of metronidazole with cysteine

Ronald P. Mason, P.David Josephy

Journal:

Journal of Inorganic Biochemistry

Year:

1985

Language:

english

File:

PDF, 349 KB

english, 1985

13

A classroom model of the α-helix

Journal:

Biochemical Education

Year:

1992

Language:

english

File:

PDF, 80 KB

english, 1992

14

A comparison of the anticarcinogenic properties of four red wine polyphenols

George J. Soleas, Linda Grass, P.David Josephy, David M. Goldberg, Eleftherios P. Diamandis

Journal:

Clinical Biochemistry

Year:

2002

Language:

english

File:

PDF, 109 KB

english, 2002

15

Reaction of Gibbs reagent (2,6-dichlorobenzoquinone 4-chloroimine) with the antioxidant BHA (3-tert.-butyl 4-hydroxyanisole): isolation and identification of the major product

P.David Josephy, Robert E. Lenkinski

Journal:

Journal of Chromatography A

Year:

1984

Language:

english

File:

PDF, 323 KB

english, 1984

16

Electron spin resonance spin trapping of thiyl, radicals from the decomposition of thionitrites

P.David Josephy, Detlef Rehorek, Edward G. Janzen

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 200 KB

english, 1984

17

Re: Proprietary Research

Journal:

Year:

2001

Language:

english

File:

PDF, 46 KB

english, 2001

18

Genetically-engineered bacteria expressing human enzymes and their use in the study of mutagens and mutagenesis

P.David Josephy

Journal:

Year:

2002

Language:

english

File:

PDF, 204 KB

english, 2002

19

Evaluation of Self-Reported Progression and Correlation of Imatinib Dose to Survival in Patients with Metastatic Gastrointestinal Stromal Tumors: An Open Cohort Study

Jerry Call, Norman J. Scherzer, P. David Josephy, Christopher Walentas

Journal:

Journal of Gastrointestinal Cancer

Year:

2010

Language:

english

File:

PDF, 232 KB

english, 2010

20

Ascorbate-enhanced Cytotoxicity of misonidazole

JOSEPHY, P. DAVID, PALCIC, BRANKO, SKARSGARD, LLOYD D.

Journal:

Year:

1978

File:

PDF, 327 KB

1978

21

Synthesis and mutagenicity of 3, 3'-dihalogenated benzidines

Savard, Shaunalea, Josephy, P. David

Journal:

Year:

1986

Language:

english

File:

PDF, 299 KB

english, 1986

22

Azo dyes based on 3,5,3′,5′-tetramethylbenzidine: Potential substitutes for carcinogenic azo dyes

P.David Josephy, Marie Weerasooriya

Journal:

Chemico-Biological Interactions

Year:

1984

Language:

english

File:

PDF, 392 KB

english, 1984

23

Peroxidative metabolism of benzidine derivatives by Salmonella typhimurium

Bryon F. De France, P.David Josephy

Journal:

Chemico-Biological Interactions

Year:

1987

Language:

english

File:

PDF, 592 KB

english, 1987

24

Binding of chlorinated benzidines to the rat hepatic aromatic hydrocarbon receptor

Peter Cikryt, P.David Josephy

Journal:

Chemico-Biological Interactions

Year:

1989

Language:

english

File:

PDF, 387 KB

english, 1989

25

Mutational spectrum of revertants in the hisD3052 allele of Salmonella typhimurium induced by hydrogen peroxide-activated benzidine

Ruth E. Wallace, P.David Josephy

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 967 KB

english, 1994

26

Hydrogen peroxide-dependent activation of benzidine to mutagenic species

P.David Josephy, R.E. Subden

Journal:

Mutation Research Letters

Year:

1984

Language:

english

File:

PDF, 408 KB

english, 1984

27

Metabolism and mutagenesis of benzidine in Salmonella typhimurium strains TA98 and TA98/1,8-DNP6

Bryon F. De France, Margaret H. Carter, P. David Josephy, Douglas W. Bryant, Dennis R. McCalla

Journal:

Mutation Research Letters

Year:

1985

Language:

english

File:

PDF, 340 KB

english, 1985

28

Inhibition of benzidine mutagenesis by nucleophiles: a study using the Ames test with hamster hepatic S9 activation

P. David Josephy, Margaret H. Carter, Mark T. Goldberg

Journal:

Mutation Research Letters

Year:

1985

Language:

english

File:

PDF, 462 KB

english, 1985

29

Prostaglandin H synthase-dependent formation of the direct-acting mutagen 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) from IQ

Lesley D. Morrison, Thomas E. Eling, P.David Josephy

Journal:

Mutation Research Letters

Year:

1993

Language:

english

File:

PDF, 531 KB

english, 1993

30

Activation of aromatic amines by prostaglandin H synthase

P. David Josephy

Journal:

Free Radical Biology and Medicine

Year:

1989

Language:

english

File:

PDF, 734 KB

english, 1989

31

Peroxidase-catalyzed benzidine binding to DNA and other macromolecules

Yasuto Tsuruta, P. David Josephy, Anver D. Rahimtula, Peter J. O'Brien

Journal:

Chemico-Biological Interactions

Year:

1985

Language:

english

File:

PDF, 881 KB

english, 1985

32

The Escherichia coli lacZ reversion mutagenicity assay

P.David Josephy

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

33

Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue™ rat tongue epithelial cells and fibroblasts

Erzsēbet Papp-Szabó, George R Douglas, Brenda L Coomber, P.David Josephy

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

34

Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines

P.David Josephy, David H Evans, Vanessa Williamson, Tracey Henry, F.Peter Guengerich

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1999

Language:

english

File:

PDF, 168 KB

english, 1999

35

Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype

F.Peter Guengerich, Asit Parikh, Robert J. Turesky, P.David Josephy

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1999

Language:

english

File:

PDF, 354 KB

english, 1999

36

Reaction of Gibbs reagent with para-substituted phenols

Josephy, P. David., Van Damme, Anjel.

Journal:

Analytical Chemistry

Year:

1984

Language:

english

File:

PDF, 276 KB

english, 1984

37

Dichlorobenzidine-DNA binding catalyzed by peroxidative activation in Salmonella typhimurium

Lillian S. DeBruin, P.David Josephy

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 1.15 MB

english, 1989

38

Hydroperoxidase I catalyzes peroxidative activation of 3,3′-dichlorobenzidine to a mutagen in Salmonella typhimurium

I.Jean McGowan-Jordan, P.David Josephy

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 1.57 MB

english, 1990

39

Acetaminophen: enzymatic formation of a transient phenoxyl free radical

Paul R. West, Laura S. Harman, P. David Josephy, Ronald p. Mason

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 313 KB

english, 1984

40

Reaction of 4-substituted phenols with benzidine in a peroxidase system

P.David Josephy, Anjel Van Damme

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 191 KB

english, 1984

41

Mutagenicity of thionitrites in the ames test: The biological activity of thiyl free radicals

Margaret H. Carter, P.David Josephy

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 394 KB

english, 1986

42

Hydrogen and thermal yields of porous metal matrix hydride compacts of MmNi4.15Fe0.85Hx

Y. Josephy, Y. Eisenberg, S. Perez, A. Ben-David, M. Ron

Journal:

Journal of the Less Common Metals

Year:

1984

Language:

english

File:

PDF, 587 KB

english, 1984

43

Functional characterization of four allelic variants of human cytochrome P450 1A2

Huijia Zhou, P.David Josephy, Donghak Kim, F.Peter Guengerich

Journal:

Archives of Biochemistry and Biophysics

Year:

2004

Language:

english

File:

PDF, 226 KB

english, 2004

44

Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties

P. David Josephy, Meredith Kent, Bengt Mannervik

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 385 KB

english, 2009

45

Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface

P. David Josephy, Dan Pan, Michael D. Ianni, Bengt Mannervik

Journal:

Archives of Biochemistry and Biophysics

Year:

2011

Language:

english

File:

PDF, 754 KB

english, 2011

46

Ames test evaluation of two commercially available zero-valent nickel compounds

P. David Josephy, Jody J. Weadge, Joseph Meissner, Filomena Ng

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2008

Language:

english

File:

PDF, 395 KB

english, 2008

47

Activation of aminoimidazole carcinogens by nitrosation: Mutagenicity and nucleotide adducts

Terry V. Zenser, Vijaya M. Lakshmi, Herman A.J. Schut, Hui-jia Zhou, P. David Josephy

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2009

Language:

english

File:

PDF, 567 KB

english, 2009

48

Reduction of misonidazole and its derivatives by xanthine oxidase

P. David Josephy, Branko Palcic, Lloyd D. Skarsgard

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 407 KB

english, 1981

49

Epithelial and fibroblast cell lines cultured from the transgenic BigBlue™ rat: an in vitro mutagenesis assay

Heather M McDiarmid, George R Douglas, Brenda L Coomber, P.David Josephy

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2001

Language:

english

File:

PDF, 344 KB

english, 2001

50

Evaluation of Escherichia coli DJ4309 expressing human P450 1A2 in mutagenicity testing of complex food mixtures

Anne Constable, Natacha Varga, P.David Josephy, Phillipe Guy, Robert J Turesky

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1999

Language:

english

File:

PDF, 175 KB

english, 1999

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